When Drugs Don’t Help
Marna Davenport, a teacher from South Carolina, suffered treatment-resistant depression for over 20 years. "I didn’t know how much longer I could go on," she says.. "I had battled the disease so long and I was tired." So she jumped at the chance to join a trial of Cyberonics VNS Therapy, an electronic device surgically implanted in the chest. It sends mild electrical pulses to the vagus nerve in the neck, which helps regulate heartbeat and breathing. The stimulation seems to lift mood.
VNS (vagus nerve stimulation) has long been used to stop epileptic seizures; when patients reported that it also eased depression, scientists put it to the test. It’s intended for people who have already tried drugs, counselling, even electric shock therapy, and is meant to be used with standard treatment, says Medical University of South Carolina neurologist Mark George, who has studied VNS.
A panel of experts recently recommended approval of VNS for depression; the final OK could come by year’s end. "I feel terrific," says Davenport.


